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      • New in the News
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    • Team
      • Dr. Glen Kenny
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      • Co-Investigators
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      • Public Health & Heat
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      • Mechanisms of Heat Loss
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      • Cellular Response
      • Health & Fitness
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      • Tour Our Lab
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  • Home
  • News
    • New in the News
    • News Archive
    • Newsletter
    • Presentations
    • Educational Material
    • Conference Engagement
    • Upcoming Events
  • Team
    • Dr. Glen Kenny
    • Postdoctoral Fellows
    • Ph.D. Students
    • M.Sc. Students
    • Undergraduate Students
    • Co-Investigators
  • Research
    • Public Health & Heat
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    • Cellular Response
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Mechanisms & Controllers of the Human Heat Stress Response

2025

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

TRPA1 channels modulate cutaneous vasodilation during exercise in the heat in young adults when NOS is inhibited.


Hattori R, Kajiki M, Fujimoto T, Amano T, Kenny GP, Watanabe K, Nishiyasu T, Fujii N. 


PMID:  39925087

DOI: 10.1152/ajpregu.00269.2024

Read More

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Separate and combined blockades of α-and β-adrenergic receptors in forearm sweating induced by adrenergic agents and exercise in the heat in young adults.


Amano T, Fujii N, Kenny GP, Mündel T, Inoue Y, Yokoyama S, Kondo N. 


PMID:  39705590

DOI: 10.1152/ajpregu.00120.2024

Read More

2024

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Modulation of cutaneous vasodilation by reactive oxygen species during local and whole-body heating in young and older adults.


McGarr GW, Li-Maloney C, King KE, Janetos KM, Fujii N, Amano T, Kenny GP.


PMID: 39241006

DOI: 10.1152/ajpregu.00127.2024

Read More

International Journal of Pharmaceutics

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Pretreatment of microneedles enhances passive transdermal administration of pilocarpine and pilocarpine-induced sweat production in humans.


Amano T, Fujii N, Kenny GP, Mündel T, Yokoyama S, Yamashita H, Quan YS.


PMID: N/A

DOI: 10.1016/j.ijpharm.2024.124497

Read More

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Exercise intensity-and body region-specific differences in sweating in middle-aged-to-older men with and without type 2 diabetes.


Kirby NV, Meade RD, Poirier MP, Notley SR, Sigal RJ, Boulay P, Kenny GP.


PMID: 38682241

DOI: 10.1152/ajpregu.00037.2024

Read More

European Journal of Applied Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

GH and IGF-1 in skin interstitial fluid at rest and during exercise in humans: insights into roles of GH and IGF-1 in the regulation of heat dissipation. 


Maimaituxun G, Amano T, Kenny GP, Mundel T, Katagiri A, Tanabe Y, Watanabe K, Nishiyasu T, Kondo N, Fujii N. 


PMID: 38446190

DOI: 10.1007/s00421-024-05448-9

Read More

2022

Experimental Physiology

Experimental Physiology

Experimental Physiology

TMEM16A blockers T16Ainh-A01 and benzbromarone do not modulate the regulation of sweating and cutaneous vasodilatation in humans in vivo.  


Fujii N, Amano T, Kenny GP, Mundel T, Lei T-H, Honda Y, Kondo N, Nishiyasu T.  


PMID: 35688020

DOI: 10.1113/EP090521

Read More

Experimental Physiology

Experimental Physiology

Experimental Physiology

Effects of tetraethylammonium-sensitive K + channel blockade on cholinergic and thermal sweating in endurance-trained and untrained men. 


Amano T, Fujii N, Kenny GP, Okamoto Y, Inoue Y, Kondo N. 

 

PMID: 35340063

DOI: 10.1113/EP090251

Read More

Physiological Reports

Journal of Cardiovascular Pharmacology

Journal of Cardiovascular Pharmacology

Revisiting regional variation in the age-related reduction in sweat rate during passive heat stress.


Schmidt M, Notley SR, Meade R, Akerman A, Rutherford M, Kenny GP. 


PMID: 35411704

DOI: 10.14814/phy2.15250

Read More

Journal of Cardiovascular Pharmacology

Journal of Cardiovascular Pharmacology

Journal of Cardiovascular Pharmacology

TRPA1 channel activation with cinnamaldehyde induces cutaneous vasodilation through NOS, but not COX and KCa channel, mechanisms in human.


Kataoka Y, Kenny GP, Nishiyasu T, Amano T, Mundel T, Zheng H, Lei T-H, Watanabe K, Fujii N. 


PMID: 34983913

DOI: 10.1097/FJC.0000000000001188

Read More

2021

Microcirculation

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Does ageing alter venoarteriolar reflex or post-occlusive reactive hyperaemia in human skin when spatial variation is considered? 


Fujii N, McGarr G, Amano T, Boulay P, Nishiyasu T, Kenny GP. 


PMID: 34874589

DOI: 10.1111/micc.12743

Read More

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

The effect of extracellular hyperosmolality on sweat rate during metaboreflex activation in passively heated young men.


Rutherford M, Akerman A, Meade R, Notley SR, Schmidt M, Kenny GP. 


PMID: 34786980

DOI: 10.1152/ajpregu.00161.2021

Read More

Experimental Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Experimental Dermatology

Regional variation in nitric oxide-dependent cutaneous vasodilatation during local heating in young adults.


McGarr GW, King KE, Saci S, Leduc D, Akerman AP, Fujii N, Kenny GP.  


PMID: 34143517

DOI: 10.1113/EP089671

Read More

Experimental Dermatology

Journal of Thermal Biology

Experimental Dermatology

Type 2 diabetes impairs vascular responsiveness to nitric oxide, but not the venoarteriolar reflex or post-occlusive reactive hyperaemia in non-glaborous forearm skin.


Fujii N, McGarr GW, Amano T, Nishiyasu T, Sigal RJ, Kenny GP. 


PMID: 34114706

DOI: 10.1111/exd.14408

Read More

Journal of Thermal Biology

Journal of Thermal Biology

Journal of Thermal Biology

Regional cutaneous vasodilator responses to rapid and gradual local heating in young adults.


Saci S, McGarr GW, Fujii N, Kenny GP. 


PMID: 34420622

DOI: 10.1016/j.jtherbio.2021.102978

Read More

Experimental Physiology

Journal of Thermal Biology

Journal of Thermal Biology

Effects of short-term heat acclimation on whole-body heat exchange, and local NOS- and COX-dependent heat loss responses in exercising older men.


Fujii N, McGarr GW, Notley SR, Boulay P, Sigal R, Amano T, Nishiyasu T, Poirier M, Kenny GP. 


PMID: 33347660

DOI: 10.1113/EP089025

Read More

Experimental Physiology

Applied Physiology, Nutrition, and Metabolism

Experimental Physiology

Myths and Methodologies: Reliability of forearm cutaneous vasodilation measured using laser‐Doppler flowmetry during whole‐body passive heating.


Gemae MR, Akerman AP, McGarr GW, Meade RD, Notley SR, Schmidt MD, Rutherford MM, Kenny GP. 


PMID: 33245579

DOI: 10.1113/EP089073

Read More

Experimental Physiology

Applied Physiology, Nutrition, and Metabolism

Experimental Physiology

Myths and Methodologies: Regional variation in the reliability of sweat rate measured via the ventilated capsule technique during passive heating.


Rutherford MM, Akerman AP, Notley SR, Meade RD, Schmidt MD, Kenny GP. 


PMID: 33230911

DOI: 10.1113/EP089074

Read More

Applied Physiology, Nutrition, and Metabolism

Applied Physiology, Nutrition, and Metabolism

Applied Physiology, Nutrition, and Metabolism

Effect of exercise-heat acclimation on cardiac autonomic modulation in Type 2 Diabetes: A pilot study.


Macartney MJ, Notley SR, Herry CL, Sigal RJ, Boulay P, Kenny GP.  


PMID: 33201735

DOI: 10.1139/apnm-2020-0785

Read More

Experimental Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Applied Physiology, Nutrition, and Metabolism

Myths and Methodologies: Reliability of non-invasive estimates of cardiac autonomic modulation during whole-body passive heating.


Akerman AP, Meade RD, Notley SR, Rutherford MM, Kenny GP. 


PMID: 33197089

DOI: 10.1113/EP089069

Read More

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

TRPV4 channels do not modulate skin vasodilation and sweating during hyperthermia or skin vasodilation during post-occlusive reactive and thermal hyperemia.


Fujii N, Kenny GP, McGarr GW, Amano T, Honda Y, Kondo N, Nishiyasu T. 


PMID: 33085914

DOI: 10.1152/ajpregu.00123.2020

Read More

Microvascular Research

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

KCa channels are major contributors to ATP-induced cutaneous vasodilation in healthy older adults.


McGarr GW, Muia CM, Fujii N, Kenny GP.  


PMID: 33058899

DOI: 10.1016/j.mvr.2020.104096

Read More

2020

Experimental Dermatology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

The relative contribution of α– and β-adrenergic sweating during heat stress and the influence of sex and training status.


Amano T, Fujii N, Kenny GP, Nishiyasu T, Yoshimitsu I, Kondo N.  


PMID: 33015872

DOI: 10.1111/exd.14208


Read More

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Effects of L-type voltage-gated Ca2+ channel blockade on cholinergic and thermal sweating in habitually trained and untrained men. 


Amano T, Fujii N, Kenny GP, Okamoto Y, Inoue Y, Konda N.  


PMID: 32966123

DOI: 10.1152/ajpregu.00167.2020

Read More

Physiological Reports

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Experimental Physiology

Heat shock protein 90 modulates cutaneous vasodilation during an exercise-heat stress, but not during passive whole-body heating in young women.


McGarr G, Fujii N, Schmidt M, Muia C, Kenny GP.  


PMID: 32845578

DOI: 10.14814/phy2.14552

Read More

Experimental Physiology

Experimental Physiology

Experimental Physiology

Ageing augments β-adrenergic cutaneous vasodilatation differently in men and women with no effects on β-adrenergic sweating.


Fujii N, McGarr GW, Amano T, Sigal RJ, Boulay P, Nishiyasu T, Kenny GP.


PMID: 32818310

DOI: 10.1113/EP088583

Read More

Experimental Physiology

Experimental Physiology

Experimental Physiology

Does the iontophoretic application of bretylium tosylate modulate sweating during exercise in the heat in habitually trained and untrained men?  


Amano T, Sekihara S, Fujii N, Kenny GP, Inoue Y, Kondo N. 


PMID: 32776611

DOI: 10.1113/EP088797

Read More

Microvascular Research

Experimental Physiology

Experimental Physiology

Sex differences in cholinergic, nicotinic, and adrenergic cutaneous vasodilation: roles of nitric oxide synthase, cyclooxygenase, and K+channels.


Fujii N, Mc Garr GW, Ghassa R, Schmidt M, McMcormick JJ, Nishiyasu T, Kenny GP. 


PMID: 32531353

DOI: 10.1016/j.mvr.2020.104030

Read More

Journal of Applied Physiology (1985)

Journal of Applied Physiology (1985)

Journal of Applied Physiology (1985)

Does α1-adrenergic receptor  modulate sweating during incremental exercise in young endurance-trained men.


Amano T, Fujii N, Kenny GP, Inoue Y, Kondo N. 


PMID: 32221728

DOI: 10.1007/s00421-020-04351-3

Read More

Experimental Physiology

Journal of Applied Physiology (1985)

Journal of Applied Physiology (1985)

Regional influence of nitric oxide on cutaneous vasodilatation and sweating during exercise-heat stress in young men.


Schmidt MD, McGarr GW, Muia C, Fujii N, Amano T, Kenny GP. 


PMID: 32176373

DOI: 10.1113/EP088388

Read More

Skin Pharmacology and Physiology

Journal of Applied Physiology (1985)

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Intradermal administration of atrial natriuretic peptide attenuates cutaneous vasodilation but not sweating in young men during exercise in the heat.


McGarr G, Fujii N, Muia C, Nishiyasu T, Kenny GP.  


PMID: 32008009

DOI: 10.1159/000505300

Read More

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

NO-mediated activation of KATP channels contribute to cutaneous thermal hyperaemia in young adults.


Fujii N, McGarr GW, Kenny GP, Amano T, Honda Y, Kondo N, Nishiyasu T.  


PMID: 31913684

DOI: 10.1152/ajpregu.00176.2019

Read More

Experimental Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Experimental Physiology

Regional contributions of nitric oxide synthase to cholinergic cutaneous vasodilation and sweating in young men.


McGarr G, Ghassa R, Fujii N, Amano T, Kenny GP.  


PMID: 31821642

DOI: 10.1113/EP088295

Read More

2019

European Journal of Pharmacology

European Journal of Pharmacology

European Journal of Pharmacology

KCa and KV channels modulate the venoarteriolar reflex in non-glabrous human skin with no roles of KATP channels, NOS, and COX.


Fujii N, McGarr GW, McNeely B, Ichinose M, Nishiyasu T, Kenny GP. 


PMID: 31790651

DOI: 10.1016/j.ejphar.2019.172828

Read More

Experimental Physiology

European Journal of Pharmacology

European Journal of Pharmacology

The nitric oxide contribution to cutaneous vasodilation and sweating in black-African and Caucasian descent men during exercise in the heat.


Muia CM, McGarr GW, Schmidt MD, Fujii N, Amano T, Kenny GP.


PMID: 31609035

DOI: 10.1113/EP088115

Read More

Experimental Physiology

European Journal of Pharmacology

Experimental Physiology

Nicotinic receptors modulate skin perfusion during normothermia, and have a limited role in skin vasodilatation and sweating during hyperthermia.


Fujii N, Amano T, Kenny GP, Honda Y, Kondo N, Nishiyasu T. 


PMID: 31608521

DOI: 10.1113/EP088072

Read More

Experimental Physiology

Skin Pharmacology and Physiology

Experimental Physiology

Ageing augments nicotinic and adenosine triphosphate-induced but not muscarinic cutaneous vasodilation in women 


Fujii N, McGarr GW, Sigal RJ, Boulay P, Nishiyasu T, Kenny GP.  


PMID: 31602716

DOI: 10.1113/EP088144

Read More

Microcirculation

Skin Pharmacology and Physiology

Skin Pharmacology and Physiology

Tetraethylammonium, glibenclamide, and 4-aminopyridine modulate post-occlusive reactive hyperaemia in non-glabrous human skin with no roles of NOS and COX.


Fujii N, McGarr GW, Ichinose M, Nishiyasu T, Kenny GP.  


PMID: 31435995

DOI: 10.1111/micc.12586

Read More

Skin Pharmacology and Physiology

Skin Pharmacology and Physiology

Skin Pharmacology and Physiology

Exogenous activation of protease-activated receptor attenuates cutaneous vasodilation and sweating in older men exercising in the heat.


Fujii N, Hatam K, McGarr GW, Meade RD, Boulay P, Nishiyasu T, Kenny GP. 

 

PMID: 31220834

DOI: 10.1159/000500643

Read More

European Journal of Pharmacology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

European Journal of Pharmacology

Evidence for TRPV4 channel induced skin vasodilation through NOS, COX, and KCa channel mechanisms with no effect on sweat rate in humans.


Fujii N, Kenny GP, Tatsuro A, Honda Y, Kondo N, Nishiyasu T.  


PMID: 31216445

DOI: 10.1016/j.ejphar.2019.172462

Read More

Microvascular Research

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

European Journal of Pharmacology

Superoxide and NADPH oxidase do not modulate skin blood flow in older exercising adults with and without type 2 diabetes.


McGarr GW, Fujii N, McNeely BD, Hatam K, Nishiyasu T, Sigal RJ, Boulay P, Kenny GP.  


PMID: 31199960

DOI: 10.1016/j.mvr.2019.103886

Read More

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Separate and combined effects of KCa and KATP channel blockade with NOS inhibition on cutaneous vasodilation and sweating in older men during heat stress.


McGarr G, Fujii N, Muia C, Nishiyasu T, Kenny GP.  


PMID: 31091157

DOI: 10.1152/ajpregu.00075.2019

Read More

Microcirculation

Journal of Applied Physiology (1985)

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Heat shock protein 90 does not contribute to cutaneous vasodilation in older males and females during rest, exercise, and recovery in the heat.


Fujii N, McGarr G, Hatam K, Chandran N, Muia C, Nishiyasu T, Boulay P, Ghassa R, Kenny GP.  


PMID: 30828931

DOI: 10.1111/micc.12541

Read More

Journal of Applied Physiology (1985)

Journal of Applied Physiology (1985)

Journal of Applied Physiology (1985)

Local arginase inhibition and low-dose sodium nitroprusside administration do not modulate heat loss responses in young and older men during exercise.


Meade R, Fujii N, McGarr G, Alexander L, Boulay P, Sigal RJ, Kenny GP.  


PMID: 30653418

DOI: 10.1152/japplphysiol.00657.2018

Read More

Experimental Dermatology

Journal of Applied Physiology (1985)

Journal of Applied Physiology (1985)

Ageing attenuates muscarinic-mediated sweating differently in men and women with no effect on nicotinic-mediated sweating.


Fujii N, McGarr GW, Nishiyasu T, Boulay P, Sigal RJ, Kenny GP. 


PMID: 30629762

DOI: 10.1111/exd.13878

Read More

2018

Temperature (Austin)

Physiological Reports

Physiological Reports

The effect of exogenous activation of protease-activated receptor 2 on cutaneous vasodilatation and sweating in young males during rest and exercise in the heat.


Fujii N, Danquah O, Meade RD, Nishiyasu T, Kenny GP. 


PMID: 30377641

DOI: 10.1080/23328940.2018.1506563

Read More

Physiological Reports

Physiological Reports

Physiological Reports

Cyclooxygenase-1 and -2 modulate sweating but not cutaneous vasodilation during exercise in the heat in young men. 


Fujii N, Pastore OL, McGarr GW, Meade RD, McNeely BD, Nishiyasu T, Kenny GP.  


PMID: 30175553

DOI: 10.14814/phy2.13844 

Read More

Microcirculation

Physiological Reports

Applied Physiology, Nutrition, and Metabolism

Ageing attenuates purinergic, but not muscarinic and nicotinic cutaneous vasodilation in men.


Fujii N, Nishiyasu T, Sigal RJ, Boulay R, McGarr W, Kenny GP. 


PMID: 29846993

DOI: 10.1111/micc.12462

Read More

Applied Physiology, Nutrition, and Metabolism

Applied Physiology, Nutrition, and Metabolism

Applied Physiology, Nutrition, and Metabolism

Postexercise whole-body sweating increases during muscle metaboreceptor activation in young men.


Friesen BJ, Poirier M, Lamarche T, D’Souza AW, Kim J-H, Notley SR, Kenny GP.  


PMID: 29316406

DOI: 10.1139/apnm-2017-0675

Read More

Applied Physiology, Nutrition, and Metabolism

Applied Physiology, Nutrition, and Metabolism

Applied Physiology, Nutrition, and Metabolism

Effect of P2 receptor blockade on cutaneous vasodilation during rest and exercise in the heat in young men.


Fujii N, Meade RD, Louie JC, Akbari P, Boulay P, Sigal RJ, Kenny GP.  


PMID: 29272631

DOI: 10.1139/apnm-2017-0700


Read More

Microvascular Research

Applied Physiology, Nutrition, and Metabolism

Applied Physiology, Nutrition, and Metabolism

Voltage-gated potassium channels contribute to a sustained cutaneous vasodilation licited by local heating through NOS-dependent mechanisms in young adults.


Fujii N, Halili L, Nishiyasu N, Kenny GP. 


PMID: 29247720

DOI: 10.1016/j.mvr.2017.12.001

Read More

Experimental Physiology

Experimental Physiology

Experimental Physiology

Type 2 diabetes specifically attenuates purinergic skin vasodilatation without affecting muscarinic and nicotinic skin vasodilatation and sweating.


Fujii N, Meade RD, McNeely BD, Nishiyasu T, Sigal RJ, Kenny GP.  


PMID: 29210478

DOI: 10.1113/EP086694

Read More

Experimental Physiology

Experimental Physiology

Experimental Physiology

Oxidative stress does not influence local sweat rate during high intesity exercise.


Meade RD, Fujii N, Poirier MP, Boulay P, Sigal RJ, Kenny GP.  


PMID: 29152797

DOI: 10.1113/EP086746

Read More

Temperature (Austin)

Experimental Physiology

Temperature (Austin)

Intradermal administration of atrial natriuretic peptide has no effect on sweating and cutaneous vasodilator responses in young male adults.


Fujii N, McNeely B, Nishiyasu T, Kenny GP.  


PMID: 29435479

DOI: 10.1080/23328940.2017

Read More

2017

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Fluid replacement modulates oxidative stress- but not nitric oxide-mediated cutaneous vasodilation and sweating during prolonged exercise in the heat.


McNeely BD, Meade RD, Fujii N, Seely AJE, Sigal RJ, Kenny GP.  


PMID: 28931548

DOI: 10.1152/ajpregu.00284.2017

Read More

Physiological Reports

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Do nitric oxide and cycloxygenase contribute to sweating response during passive heating in endurance-trained athletes?


Amano T, Fujii N, Kenny GP, Inoue Y, Kondo N.  


PMID: 28899912

DOI: 10.14814/phy2.13403

Read More

Journal of Applied Physiology (1985)

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Journal of Applied Physiology (1985)

Heat shock protein 90 contributes to cutaneous vasodilation through activating nitric oxide synthase in young male adults exercising in the heat.


Fujii N, Zhang S, McNeely B, Nishiyasu T, Kenny GP. 


PMID: 28751373

DOI: 10.1152/japplphysiol.00446.2017

Read More

Physiological Reports

Physiological Reports

Journal of Applied Physiology (1985)

No effect of ascorbate on cutaneous vasodilation and sweating in older men and those with type 2 diabetes exercising in the heat.


Fujii N, Meade R, Akbari P, Louie J, Alexander L, Boulay P, Sigal RJ, Kenny GP.  


PMID: 28400505

DOI: 10.14814/phy2.13238

Read More

Physiological Reports

Physiological Reports

Physiological Reports

Individuals variations in nitric oxide synthase dependent sweating in young and older males during exercise in the heat: role of aerobic power.


Amano T, Fujii, Louie J, Meade R.  Kenny GP.  


PMID: 28325791

DOI: 10.14814/phy2.13208

Read More

Physiological Reports

Physiological Reports

Physiological Reports

The mechanisms underlying the muscle metaboreflex modulation of sweating and cutaneous blood flow in passively heated humans.


Haqani B, Fujii N, Kondo N, Kenny GP.  


PMID: 28183862

DOI: 10.14814/phy2.13123

Read More

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

The roles of KCa, KATP, KV channels in regulating cutaneous vasodilation and sweating during exercise in the heat.


Louie JC, Fujii N, Meade R, McNeely B, Kenny GP.  


PMID: 28254750

DOI: 10.1152/ajpregu.00507.2016

Read More

Experimental Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Prostacyclin does not affect sweating but induces skin vasodilatation to a greater extent in older versus younger women: roles of NO and KCa channels.


Fujii N, McNeely BD, Nishiyasu T, Kenny GP.  


PMID: 28271565

DOI: 10.1113/EP086297

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Applied Physiology, Nutrition, and Metabolism

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Applied Physiology, Nutrition, and Metabolism

Mechanisms of nicotine-induced cutaneous vasodilation and sweating in young adults: roles for KCa, KATP, and KV channels, nitric oxide, and prostanoids.


Fujii, N, Louie JC, McNeely B, Amano T, Nishiyasu T, Kenny GP.  


PMID: 28177721

DOI: 10.1139/apnm-2016-0615

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Experimental Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Applied Physiology, Nutrition, and Metabolism

Activation of protease-activated receptor 2 mediates cutaneous vasodilatation but not sweating: roles of nitric oxide synthase and cyclooxygenase.


Fujii N, McNeely BD, Zhang S, Abdellaoui YC, Danquah MO, Kenny GP. 


PMID: 27981668

DOI: 10.1113/EP086092

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American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Intradermal administration of endothelin-1 attenuates endothelin-dependent and –independent cutaneous vasodilation via Rho kinase in young adults.


Fujii N, Amano T, Halili L, Louie JC, Zhang SY, McNeely B, Kenny GP.  


PMID: 27881399

DOI: 10.1152/ajpregu.00368.2016

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Experimental Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Nicotinic receptor activation augments muscarinic receptor-mediated sweating but not cutaneous vasodilatation in young males.


Fujii N, Louie JC, McNeely BD, Zhang SY, Tran MY, Kenny GP.  


PMID: 27859779

DOI: 10.1113/EP085916

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