Mechanisms & Controllers of the Human Heat Stress Response

Does ageing alter venoarteriolar reflex or post-occlusive reactive hyperaemia in human skin when spatial variation is considered? 

Fujii N, McGarr G, Amano T, Boulay P, Nishiyasu T, Kenny GP. 

PMID: 34874589

DOI: 10.1111/micc.12743

The effect of extracellular hyperosmolality on sweat rate during metaboreflex activation in passively heated young men.

Rutherford M, Akerman A, Meade R, Notley SR, Schmidt M, Kenny GP. 

PMID: 34786980

DOI: 10.1152/ajpregu.00161.2021

Regional variation in nitric oxide-dependent cutaneous vasodilatation during local heating in young adults.

McGarr GW, King KE, Saci S, Leduc D, Akerman AP, Fujii N, Kenny GP.  

PMID: 34143517

DOI: 10.1113/EP089671

Type 2 diabetes impairs vascular responsiveness to nitric oxide, but not the venoarteriolar reflex or post-occlusive reactive hyperaemia in non-glaborous forearm skin.

Fujii N, McGarr GW, Amano T, Nishiyasu T, Sigal RJ, Kenny GP. 

PMID: 34114706

DOI: 10.1111/exd.14408

Regional cutaneous vasodilator responses to rapid and gradual local heating in young adults.

Saci S, McGarr GW, Fujii N, Kenny GP. 

PMID: 34420622

DOI: 10.1016/j.jtherbio.2021.102978

Effects of short-term heat acclimation on whole-body heat exchange, and local NOS- and COX-dependent heat loss responses in exercising older men.

Fujii N, McGarr GW, Notley SR, Boulay P, Sigal R, Amano T, Nishiyasu T, Poirier M, Kenny GP. 

PMID: 33347660

DOI: 10.1113/EP089025

Myths and Methodologies: Reliability of forearm cutaneous vasodilation measured using laser‐Doppler flowmetry during whole‐body passive heating.

Gemae MR, Akerman AP, McGarr GW, Meade RD, Notley SR, Schmidt MD, Rutherford MM, Kenny GP. 

PMID: 33245579

DOI: 10.1113/EP089073

Myths and Methodologies: Regional variation in the reliability of sweat rate measured via the ventilated capsule technique during passive heating.

Rutherford MM, Akerman AP, Notley SR, Meade RD, Schmidt MD, Kenny GP. 

PMID: 33230911

DOI: 10.1113/EP089074

Effect of exercise-heat acclimation on cardiac autonomic modulation in Type 2 Diabetes: A pilot study.

Macartney MJ, Notley SR, Herry CL, Sigal RJ, Boulay P, Kenny GP.  

PMID: 33201735

DOI: 10.1139/apnm-2020-0785

Myths and Methodologies: Reliability of non-invasive estimates of cardiac autonomic modulation during whole-body passive heating.

Akerman AP, Meade RD, Notley SR, Rutherford MM, Kenny GP. 

PMID: 33197089

DOI: 10.1113/EP089069

TRPV4 channels do not modulate skin vasodilation and sweating during hyperthermia or skin vasodilation during post-occlusive reactive and thermal hyperemia.

Fujii N, Kenny GP, McGarr GW, Amano T, Honda Y, Kondo N, Nishiyasu T. 

PMID: 33085914

DOI: 10.1152/ajpregu.00123.2020

KCa channels are major contributors to ATP-induced cutaneous vasodilation in healthy older adults.

McGarr GW, Muia CM, Fujii N, Kenny GP.  

PMID: 33058899

DOI: 10.1016/j.mvr.2020.104096

KCa and KV channels modulate the venoarteriolar reflex in non-glabrous human skin with no roles of KATP channels, NOS, and COX.

Fujii N, McGarr GW, McNeely B, Ichinose M, Nishiyasu T, Kenny GP. 

PMID: 31790651

DOI: 10.1016/j.ejphar.2019.172828

The nitric oxide contribution to cutaneous vasodilation and sweating in black-African and Caucasian descent men during exercise in the heat.

Muia CM, McGarr GW, Schmidt MD, Fujii N, Amano T, Kenny GP.

PMID: 31609035

DOI: 10.1113/EP088115

Nicotinic receptors modulate skin perfusion during normothermia, and have a limited role in skin vasodilatation and sweating during hyperthermia.

Fujii N, Amano T, Kenny GP, Honda Y, Kondo N, Nishiyasu T. 

PMID: 31608521

DOI: 10.1113/EP088072

Ageing augments nicotinic and adenosine triphosphate-induced but not muscarinic cutaneous vasodilation in women 

Fujii N, McGarr GW, Sigal RJ, Boulay P, Nishiyasu T, Kenny GP.  

PMID: 31602716

DOI: 10.1113/EP088144

Tetraethylammonium, glibenclamide, and 4-aminopyridine modulate post-occlusive reactive hyperaemia in non-glabrous human skin with no roles of NOS and COX.

Fujii N, McGarr GW, Ichinose M, Nishiyasu T, Kenny GP.  

PMID: 31435995

DOI: 10.1111/micc.12586

Exogenous activation of protease-activated receptor attenuates cutaneous vasodilation and sweating in older men exercising in the heat.

Fujii N, Hatam K, McGarr GW, Meade RD, Boulay P, Nishiyasu T, Kenny GP. 

PMID: 31220834

DOI: 10.1159/000500643

Evidence for TRPV4 channel induced skin vasodilation through NOS, COX, and KCa channel mechanisms with no effect on sweat rate in humans.

Fujii N, Kenny GP, Tatsuro A, Honda Y, Kondo N, Nishiyasu T.  

PMID: 31216445

DOI: 10.1016/j.ejphar.2019.172462

Superoxide and NADPH oxidase do not modulate skin blood flow in older exercising adults with and without type 2 diabetes.

McGarr GW, Fujii N, McNeely BD, Hatam K, Nishiyasu T, Sigal RJ, Boulay P, Kenny GP.  

PMID: 31199960

DOI: 10.1016/j.mvr.2019.103886

Separate and combined effects of KCa and KATP channel blockade with NOS inhibition on cutaneous vasodilation and sweating in older men during heat stress.

McGarr G, Fujii N, Muia C, Nishiyasu T, Kenny GP.  

PMID: 31091157

DOI: 10.1152/ajpregu.00075.2019

Heat shock protein 90 does not contribute to cutaneous vasodilation in older males and females during rest, exercise, and recovery in the heat.

Fujii N, McGarr G, Hatam K, Chandran N, Muia C, Nishiyasu T, Boulay P, Ghassa R, Kenny GP.  

PMID: 30828931

DOI: 10.1111/micc.12541

Local arginase inhibition and low-dose sodium nitroprusside administration do not modulate heat loss responses in young and older men during exercise.

Meade R, Fujii N, McGarr G, Alexander L, Boulay P, Sigal RJ, Kenny GP.  

PMID: 30653418

DOI: 10.1152/japplphysiol.00657.2018

Ageing attenuates muscarinic-mediated sweating differently in men and women with no effect on nicotinic-mediated sweating.

Fujii N, McGarr GW, Nishiyasu T, Boulay P, Sigal RJ, Kenny GP. 

PMID: 30629762

DOI: 10.1111/exd.13878

Fluid replacement modulates oxidative stress- but not nitric oxide-mediated cutaneous vasodilation and sweating during prolonged exercise in the heat.

McNeely BD, Meade RD, Fujii N, Seely AJE, Sigal RJ, Kenny GP.  

PMID: 28931548

DOI: 10.1152/ajpregu.00284.2017

Do nitric oxide and cycloxygenase contribute to sweating response during passive heating in endurance-trained athletes?

Amano T, Fujii N, Kenny GP, Inoue Y, Kondo N.  

PMID: 28899912

DOI: 10.14814/phy2.13403

Heat shock protein 90 contributes to cutaneous vasodilation through activating nitric oxide synthase in young male adults exercising in the heat.

Fujii N, Zhang S, McNeely B, Nishiyasu T, Kenny GP. 

PMID: 28751373

DOI: 10.1152/japplphysiol.00446.2017

No effect of ascorbate on cutaneous vasodilation and sweating in older men and those with type 2 diabetes exercising in the heat.

Fujii N, Meade R, Akbari P, Louie J, Alexander L, Boulay P, Sigal RJ, Kenny GP.  

PMID: 28400505

DOI: 10.14814/phy2.13238

Individuals variations in nitric oxide synthase dependent sweating in young and older males during exercise in the heat: role of aerobic power.

Amano T, Fujii, Louie J, Meade R.  Kenny GP.  

PMID: 28325791

DOI: 10.14814/phy2.13208

The mechanisms underlying the muscle metaboreflex modulation of sweating and cutaneous blood flow in passively heated humans.

Haqani B, Fujii N, Kondo N, Kenny GP.  

PMID: 28183862

DOI: 10.14814/phy2.13123

The roles of KCa, KATP, KV channels in regulating cutaneous vasodilation and sweating during exercise in the heat.

Louie JC, Fujii N, Meade R, McNeely B, Kenny GP.  

PMID: 28254750

DOI: 10.1152/ajpregu.00507.2016

Prostacyclin does not affect sweating but induces skin vasodilatation to a greater extent in older versus younger women: roles of NO and KCa channels.

Fujii N, McNeely BD, Nishiyasu T, Kenny GP.  

PMID: 28271565

DOI: 10.1113/EP086297

Mechanisms of nicotine-induced cutaneous vasodilation and sweating in young adults: roles for KCa, KATP, and KV channels, nitric oxide, and prostanoids.

Fujii, N, Louie JC, McNeely B, Amano T, Nishiyasu T, Kenny GP.  

PMID: 28177721

DOI: 10.1139/apnm-2016-0615

Activation of protease-activated receptor 2 mediates cutaneous vasodilatation but not sweating: roles of nitric oxide synthase and cyclooxygenase.

Fujii N, McNeely BD, Zhang S, Abdellaoui YC, Danquah MO, Kenny GP. 

PMID: 27981668

DOI: 10.1113/EP086092

Intradermal administration of endothelin-1 attenuates endothelin-dependent and –independent cutaneous vasodilation via Rho kinase in young adults.

Fujii N, Amano T, Halili L, Louie JC, Zhang SY, McNeely B, Kenny GP.  

PMID: 27881399

DOI: 10.1152/ajpregu.00368.2016

Nicotinic receptor activation augments muscarinic receptor-mediated sweating but not cutaneous vasodilatation in young males.

Fujii N, Louie JC, McNeely BD, Zhang SY, Tran MY, Kenny GP.  

PMID: 27859779

DOI: 10.1113/EP085916