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      • New in the News
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      • Dr. Glen Kenny
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      • Co-Investigators
    • Research
      • Public Health & Heat
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      • Thermoregulation & Heat
      • Mechanisms of Heat Loss
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      • Cellular Response
      • Health & Fitness
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      • Tour Our Lab
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  • Home
  • News
    • New in the News
    • News Archive
    • Newsletter
    • Presentations
    • Educational Material
    • Conference Engagement
    • Upcoming Events
  • Team
    • Dr. Glen Kenny
    • Postdoctoral Fellows
    • Ph.D. Students
    • M.Sc. Students
    • Undergraduate Students
    • Co-Investigators
  • Research
    • Public Health & Heat
    • Occupational Heat Stress
    • Thermoregulation & Heat
    • Mechanisms of Heat Loss
    • Cardiovascular Function
    • Cellular Response
    • Health & Fitness
    • Other
  • Facilities
    • Tour Our Lab
    • Research Facilities
    • The Snellen Calorimeter
    • Environmental Chamber
  • Work with Us
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Cold/Heat Exposure & the Cellular Stress Response

2025

Experimental Physiology

Applied Physiology, Nutrition, and Metabolism

Applied Physiology, Nutrition, and Metabolism

Intestinal epithelial injury and inflammation after physical work in temperate and hot environments in older men with hypertension or type 2 diabetes.


Lee BJ, Flood TR, Russell SL, McCormick JJ, King KE, Fujii N, Amano T, Notley S, Kenny GP. 


PMID: 40159416

DOI: 10.1113/EP092567

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Applied Physiology, Nutrition, and Metabolism

Applied Physiology, Nutrition, and Metabolism

Applied Physiology, Nutrition, and Metabolism

Brain-derived neurotrophic factor response to daylong exposure to extreme heat in young and older adults: A secondary analysis.


Kirby NV, Meade RD, McCormick JJ, King KE, Kenny GP. 


PMID: Coming soon

DOI: 10.1139/apnm-2024-0289

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Applied Physiology, Nutrition, and Metabolism

Applied Physiology, Nutrition, and Metabolism

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Effect of Brief Ambient Cooling on Serum Stress Biomarkers in Older Adults During a Daylong Heat Exposure: A Laboratory-Based Heat Wave Simulation.


Lee B, Meade RD, Davey SL, Thake CD, McCormick JJ, King KE, Kenny GP. 


PMID: Coming soon

DOI: 10.1139/apnm-2024-0476

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American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

The effect of an exercise- and passive-induced heat stress on autophagy in young and older males.


McCormick JJ, King KE, Goulet N, Carrillo AE, Fujii N, Amano T, Boulay P, Kenny GP. 


PMID: 39903041

DOI: 10.1152/ajpregu.00232.2024

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Applied Physiology, Nutrition, and Metabolism

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Applied Physiology, Nutrition, and Metabolism

Effects of daylong exposure to indoor overheating on enterocyte damage and inflammatory responses in older adults: A randomized crossover trial.


Lee B, Meade RD, Davey SL, Thake CD, McCormick JJ, King KE, Kenny GP.


PMID: 39869857

DOI: 10.1139/apnm-2024-0368

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2024

Advanced Biology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

The Effect of 7-Day Cold Water Acclimation on Autophagic and Apoptotic Responses in Young Males.


King KE, McCormick JJ, Kenny GP.


PMID: 39601474

DOI: 10.1002/adbi.202400111

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American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

The effect of high-intensity exercise in temperate and hot ambient conditions on autophagy and the cellular stress response in young and older females.


McCormick JJ, Goulet N, King KE, Fujii N, Amano T, Kenny GP. 


PMID: 39601770

DOI: 10.1152/ajpregu.00178.2024

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European Journal of Applied Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Applied Physiology, Nutrition, and Metabolism

Brain-derived neurotrophic factor in older adults exposed to simulated indoor overheating.


Kirby NV, Meade RD, McCormick JJ, King KE, Notley SR, Kenny GP.


PMID: 39417862

DOI: 10.1007/s00421-024-05623-y

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Applied Physiology, Nutrition, and Metabolism

Applied Physiology, Nutrition, and Metabolism

Applied Physiology, Nutrition, and Metabolism

Markers of enterocyte damage, microbial translocation and systemic inflammation following 9 hours of heat exposure in young and older adults.


Lee BJ, Russell SL, Meade RD, McCormick JJ, King KE, Kenny GP.


PMID: 38772045

DOI: 10.1139/apnm-2024-0094

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European Journal of Applied Physiology

Applied Physiology, Nutrition, and Metabolism

European Journal of Applied Physiology

Impacts of age, type 2 diabetes, and hypertension on circulating neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 after prolonged work in the heat in men.


Lee BJ, Flood TR, Russell SL, McCormick JJ, Fujii N, Kenny GP.


PMID: 38753017

DOI: 10.1007/s00421-024-05505-3

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Journal of Thermal Biology

Applied Physiology, Nutrition, and Metabolism

European Journal of Applied Physiology

Impaired autophagy following ex vivo cooling of simulated hypothermic temperatures in peripheral blood mononuclear cells from young and older adults.


King KE, McCormick J, McManus M, Janetos K-MT, Goulet N, Kenny GP.


PMID: 38565070

DOI: 10.1016/j.jtherbio.2024.103831

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Applied Physiology, Nutrition, and Metabolism

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Applied Physiology, Nutrition, and Metabolism

Greater hyperthermia in men with type 2 diabetes does not lead to higher serum levels of cellular stress biomarkers following exercise-heat stress.


Goulet N, Tetzlaff EJ, McCormick JJ, King KE, Janetos KMT, Sigal RJ, Boulay P, Kenny GP.


PMID: 38507777

DOI: 10.1139/apnm-2023-0599

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Applied Physiology, Nutrition, and Metabolism

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Applied Physiology, Nutrition, and Metabolism

Effect of daylong exposure to indoor overheating on autophagy and the cellular stress response in older adults.


McCormick JJ, Meade RD, King KE, Akerman AP, Notley SR, Kirby NV, Sigal R, Kenny GP.


PMID: 38394645

DOI: 10.1139/apnm-2023-0361

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American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

The intensity-dependent effects of exercise and superimposing environmental heat stress on autophagy in peripheral blood mononuclear cells from older men.


McCormick JJ, McManus MK, King KE, Goulet N, Kenny GP. 


PMID: 37955130

DOI: 10.1152/ajpregu.00163.2023.

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Advanced Biology (Weinh)

Advanced Biology (Weinh)

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Temperature-dependent relationship of autophagy and apoptotic signaling during cold-water immersion in young and older males.


King KE, McCormick JJ, Kenny GP. 


PMID: 38150671

DOI: 10.1002/adbi.202300560

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2023

Journal of Applied Physiology (1985)

European Journal of Applied Physiology

Journal of Applied Physiology (1985)

Brief ambient cooling preserves autophagy in older adults exposed to a 9-hour simulated heat wave.  


McCormick J, Meade RD, King K, Notley SR, Akerman A, Sigal RJ, Kenny GP.


PMID: 37707866

DOI: 10.1152/japplphysiol.00537.2023

Read Here

Journal of Applied Physiology (1985)

European Journal of Applied Physiology

Journal of Applied Physiology (1985)

Physiological responses to 9 hours of heat exposure in young and older adults: Part II - Autophagy and the acute cellular stress response.


McCormick JJ, Meade RD, King KE, Notley SR, Akerman AP, McGarr GW, Richards BJ, McCourt ER, Boulay P, Sigal RJ, Kenny GP. 


PMID: 37471211

DOI: 10.1152/japplphysiol.00411.2023

Read Here

European Journal of Applied Physiology

European Journal of Applied Physiology

European Journal of Applied Physiology

Serum klotho concentrations in older men with hypertension or type 2 diabetes during prolonged exercise in temperate and hot conditions. 


King KE, McCormick JJ, Notley SR, Boulay P, Fujii N, Amano T, Kenny GP. 


PMID: 36929016

DOI: 10.1007/s00421-023-05171-x

Read Here

2022

Journal of Thermal Biology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

The serum irisin response to prolonged physical activity in temperate and hot environments in older men with hypertension or type 2 diabetes.


McCormick JJ, King KE, Notley SR, Fujii N, Boulay P, Sigal RJ, Amano T, Kenny GP.  


PMID: 36462879

DOI: 10.1016/j.jtherbio.2022.103344

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American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Autophagic response to exercise in peripheral blood mononuclear cells from young men is intensity-dependent and is altered by exposure to environmental heat. 


McCormick JJ, Côté MD, King KE, McManus MK, Goulet N, Dokladny K, Kenny GP. 

 

PMID: 35993558

DOI: 10.1152/ajpregu.00110.2022

Read Here

Current Aging Science

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Journal of Applied Physiology (1985)

Serum klotho concentrations in young and older men during prolonged exercise in temperate and hot conditions. 


King KE, McCormick JJ, Notley SR, Fujii N, Kenny GP.  


PMID: 35249521 

DOI: 10.2174/1874609815666220304200939

 

Read Here

Journal of Applied Physiology (1985)

Journal of Applied Physiology (1985)

Journal of Applied Physiology (1985)

Effect of extracellular hyperosmolality during normothermia and hyperthermia on the autophagic response in peripheral blood mononuclear cells from young men. 


McCormick J, King K, Rutherford M, Meade R, Notley SR, Akerman A, Dokladny K, Kenny GP.  


PMID: 35238651

DOI: 10.1152/japplphysiol.00661.2021

Read Here

Journal of Thermal Biology

Journal of Applied Physiology (1985)

Journal of Thermal Biology

Exercise in the heat induces similar elevations in serum irisin in young and older men despite blunted irisin expression in older adults. 


McCormick JJ, King KE, Notley SR, Fujii P, Sigal RJ, Kenny GP.


PMID: 35180967

DOI: 10.1016/j.jtherbio.2022.103189

Read Here

2021

Journal of Thermal Biology

Journal of Applied Physiology (1985)

Journal of Applied Physiology (1985)

Impaired autophagy following ex vivo heating at physiologically relevant temperatures in peripheral blood mononuclear cells from elderly adults. 


McCormick JJ, King KE, Côté MD, Meade RD, Akerman AP, Kenny GP. 


PMID: 33454031

DOI: 10.1016/j.jtherbio.2020.102790  

Read Here

Journal of Applied Physiology (1985)

Journal of Applied Physiology (1985)

Journal of Applied Physiology (1985)

Autophagy and heat: a potential role for heat therapy to improve autophagic function in health and disease.


McCormick JJ, Dokladny K, Moseley PL, Kenny GP.


PMID: 33119472

DOI: 10.1152/japplphysiol.00542.2020 

Read Here

2020

Temperature (Austin)

Applied Physiology, Nutrition, and Metabolism

Journal of Thermal Biology

Effects of exercise-heat stress on circulating stress hormones and interleukin-6 in young and older men. 


Kaltsatou A, Notley SR, Kenny GP. 


PMID: 33251283

DOI: 10.1080/23328940.2020.1768032

Read More

Journal of Thermal Biology

Applied Physiology, Nutrition, and Metabolism

Journal of Thermal Biology

Regulation of autophagy following ex vivo heating in peripheral blood mononuclear cells from young adults. 


McCormick JJ, King KE, Côté MD, McManus MK, Topshee SM, Hsu HS, Fujii N, Kenny GP.  


PMID: 32716884

DOI: 10.1016/j.jtherbio.2020.102643

Read More

Applied Physiology, Nutrition, and Metabolism

Applied Physiology, Nutrition, and Metabolism

Applied Physiology, Nutrition, and Metabolism

Blunted circulating irisin in adults with type 1 diabetes during aerobic exercise in a hot environment. 


McCormick JJ, Notley SR, Yardley JE, Sigal RJ, Kenny GP. 


PMID: 32053388

DOI: 10.1139/apnm-2019-0624

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2019

Journal of Applied Physiology (1985)

Seven days of cold acclimation substantially increases non-shivering thermogenesis in adult humans.


Gordon K, Blondin DP, Friesen B, Tingelstad HC, Kenny GP, Haman F. 


PMID: 30896355

DOI: 10.1152/japplphysiol.01133.2018

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2018

Experimental Physiology

Oxidative stress does not influence local sweat rate during high intensity exercise.  


Meade RD, Fujii N, Poirier MP, Boulay P, Sigal RJ, Kenny GP.  


PMID: 29152797

DOI: 10.1113/EP086746

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2014

European Journal of Applied Physiology

Increased air velocity during exercise in the heat leads to equal reductions in hydration shifts and interleukin-6 with age. 


Wright-Beatty HE, Hardcastle SG, Boulay P, Larose J, Kenny GP.  


PMID: 24943735

DOI: 10.1007/s00421-014-2931-9

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2012

Journal of Occupational and Environmental Hygiene

Cortisol and interleukin-6 responses during intermittent exercise in two different hot environments with equivalent WBGT. 


Wright HE, McLellan TM, Stapleton JM, Hardcastle SG, Kenny GP.  


PMID: 22482790

DOI: 10.1080/15459624.2012.666467

Read More

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