Elucidating the mechanisms of skin blood flow and sweating

Local arginase inhibition does not modulate cutaneous vasodilation or sweating in young and older men during exercise. Meade RD, Fujii N, McGarr GW, Alexander LM, Boulay P, Sigal RJ, Kenny GP. J Appl Physiol (1985). 2019 Jan 17. doi: 10.1152/japplphysiol.00657.2018. [Epub ahead of print]: https://www.ncbi.nlm.nih.gov/pubmed/30653418


Ageing attenuates muscarinic-mediated sweating differently in men and women with no effect on nicotinic-mediated sweating. Fujii N, McGarr GW, Nishiyasu T, Sigal RJ, Boulay P, Kenny GP. Exp Dermatol. 2019 Jan 10. doi: 10.1111/exd.13878. [Epub ahead of print]: https://www.ncbi.nlm.nih.gov/pubmed/30629762


The effect of exogenous activation of protease-activated receptor 2 on cutaneous vasodilatation and sweating in young males during rest and exercise in the heat. Fujii N, Danquah MO, Meade RD, Nishiyasu T, Kenny GP. Temperature (Austin). 2018 Sep 6;5(3):257-266. doi: 10.1080/23328940.2018.1506563. eCollection 2018.: https://www.ncbi.nlm.nih.gov/pubmed/30377641


Cyclooxygenase-1 and -2 modulate sweating but not cutaneous vasodilation during exercise in the heat in young men. Fujii N, Pastore OL, McGarr GW, Meade RD, McNeely BD, Nishiyasu T, Kenny GP. Physiol Rep. 2018 Sep;6(17):e13844. doi: 10.14814/phy2.13844.:

 https://www.ncbi.nlm.nih.gov/pubmed/30175553


 Aging attenuates adenosine triphosphate-induced, but not muscarinic and nicotinic, cutaneous vasodilation in men. Fujii N, Nishiyasu T, Sigal RJ, Boulay P, McGarr GW, Kenny GP. Microcirculation. 2018 Jul;25(5):e12462. doi: 10.1111/micc.12462. Epub 2018 Jun 19.:

https://www.ncbi.nlm.nih.gov/pubmed/29846993


Intradermal administration of atrial natriuretic peptide has no effect on sweating and cutaneous vasodilator responses in young male adults. Fujii N, McNeely BD, Nishiyasu T, Kenny GP. Temperature (Austin). 2017 Oct 9;4(4):406-413. doi: 10.1080/23328940.2017.1356433. eCollection 2017.: https://www.ncbi.nlm.nih.gov/pubmed/29435479


Effect of P2 receptor blockade on cutaneous vasodilation during rest and exercise in the heat in young men. Fujii N, Meade RD, Louie JC, Akbari P, Boulay P, Sigal RJ, Kenny GP. Appl Physiol Nutr Metab. 2018 Mar;43(3):312-315. doi: 10.1139/apnm-2017-0700. Epub 2017 Dec 22.: 

https://www.ncbi.nlm.nih.gov/pubmed/29272631


Voltage-gated potassium channels and NOS contribute to a sustained cutaneous vasodilation elicited by local heating in an interactive manner in young adults. Fujii N, Halili L, Nishiyasu T, Kenny GP. Microvasc Res. 2018 May;117:22-27. doi: 10.1016/j.mvr.2017.12.001. Epub 2017 Dec 13.: https://www.ncbi.nlm.nih.gov/pubmed/29247720


Type 2 diabetes specifically attenuates purinergic skin vasodilatation without affecting muscarinic and nicotinic skin vasodilatation and sweating. Fujii N, Meade RD, McNeely BD, Nishiyasu T, Sigal RJ, Kenny GP. Exp Physiol. 2018 Feb 1;103(2):212-221. doi: 10.1113/EP086694. Epub 2018 Jan 10.: 

https://www.ncbi.nlm.nih.gov/pubmed/29210478


Oxidative stress does not influence local sweat rate during high-intensity exercise. Meade RD, Fujii N, Poirier MP, Boulay P, Sigal RJ, Kenny GP. Exp Physiol. 2018 Feb 1;103(2):172-178. doi: 10.1113/EP086746. Epub 2017 Dec 20.: https://www.ncbi.nlm.nih.gov/pubmed/29152797


 Fluid replacement modulates oxidative stress- but not nitric oxide-mediated cutaneous vasodilation and sweating during prolonged exercise in the heat. McNeely BD, Meade RD, Fujii N, Seely AJE, Sigal RJ, Kenny GP. Am J Physiol Regul Integr Comp Physiol. 2017 Dec 1;313(6):R730-R739. doi: 10.1152/ajpregu.00284.2017. Epub 2017 Sep 20.: https://www.ncbi.nlm.nih.gov/pubmed/28931548


Do nitric oxide synthase and cyclooxygenase contribute to sweating response during passive heating in endurance-trained athletes? Amano T, Fujii N, Kenny GP, Inoue Y, Kondo N. Physiol Rep. 2017 Sep;5(17). pii: e13403. doi: 10.14814/phy2.13403.: https://www.ncbi.nlm.nih.gov/pubmed/28899912


Heat shock protein 90 contributes to cutaneous vasodilation through activating nitric oxide synthase in young male adults exercising in the heat. Fujii N, Zhang SY, McNeely BD, Nishiyasu T, Kenny GP. J Appl Physiol (1985). 2017 Oct 1;123(4):844-850. doi: 10.1152/japplphysiol.00446.2017. Epub 2017 Jul 27.: https://www.ncbi.nlm.nih.gov/pubmed/28751373


No effect of ascorbate on cutaneous vasodilation and sweating in older men and those with type 2 diabetes exercising in the heat. Fujii N, Meade RD, Akbari P, Louie JC, Alexander LM, Boulay P, Sigal RJ, Kenny GP. Physiol Rep. 2017 Apr;5(7). pii: e13238. doi: 10.14814/phy2.13238.:

 https://www.ncbi.nlm.nih.gov/pubmed/28400505


 Individual variations in nitric oxide synthase-dependent sweating in young and older males during exercise in the heat: role of aerobic power. Amano T, Fujii N, Louie JC, Meade RD, Kenny GP. Physiol Rep. 2017 Mar;5(6). pii: e13208. doi: 10.14814/phy2.13208.: https://www.ncbi.nlm.nih.gov/pubmed/28325791


Prostacyclin does not affect sweating but induces skin vasodilatation to a greater extent in older versus younger women: roles of NO and K(Ca) channels. Fujii N, McNeely BD, Nishiyasu T, Kenny GP. Exp Physiol. 2017 May 1;102(5):578-586. doi: 10.1113/EP086297. Epub 2017 Mar 29.: 

https://www.ncbi.nlm.nih.gov/pubmed/28271565


The roles of K(Ca), K(ATP), and K(V) channels in regulating cutaneous vasodilation and sweating during exercise in the heat. Louie JC, Fujii N, Meade RD, McNeely BD, Kenny GP. Am J Physiol Regul Integr Comp Physiol. 2017 May 1;312(5):R821-R827. doi: 10.1152/ajpregu.00507.2016. Epub 2017 Mar 2.: https://www.ncbi.nlm.nih.gov/pubmed/28254750


The mechanisms underlying the muscle metaboreflex modulation of sweating and cutaneous blood flow in passively heated humans. Haqani B, Fujii N, Kondo N, Kenny GP. Physiol Rep. 2017 Feb;5(3). pii: e13123. doi: 10.14814/phy2.13123.: https://www.ncbi.nlm.nih.gov/pubmed/28183862


Mechanisms of nicotine-induced cutaneous vasodilation and sweating in young adults: roles for K(Ca), K(ATP), and K(V) channels, nitric oxide, and prostanoids. Fujii N, Louie JC, McNeely BD, Amano T, Nishiyasu T, Kenny GP. Appl Physiol Nutr Metab. 2017 May;42(5):470-478. doi: 10.1139/apnm-2016-0615. Epub 2017 Mar 22.: https://www.ncbi.nlm.nih.gov/pubmed/28177721


Activation of protease-activated receptor 2 mediates cutaneous vasodilatation but not sweating: roles of nitric oxide synthase and cyclo-oxygenase. Fujii N, McNeely BD, Zhang SY, Abdellaoui YC, Danquah MO, Kenny GP. Exp Physiol. 2017 Feb 1;102(2):265-272. doi: 10.1113/EP086092.:

 https://www.ncbi.nlm.nih.gov/pubmed/27981668


The roles of the Na+/K+-ATPase, NKCC, and K+ channels in regulating local sweating and cutaneous blood flow during exercise in humans in vivo. Louie JC, Fujii N, Meade RD, Kenny GP. Physiol Rep. 2016 Nov;4(22). pii: e13024.: https://www.ncbi.nlm.nih.gov/pubmed/27881572


Intradermal administration of endothelin-1 attenuates endothelium-dependent and -independent cutaneous vasodilation via Rho kinase in young adults. Fujii N, Amano T, Halili L, Louie JC, Zhang SY, McNeely BD, Kenny GP. Am J Physiol Regul Integr Comp Physiol. 2017 Jan 1;312(1):R23-R30. doi: 10.1152/ajpregu.00368.2016. Epub 2016 Nov 23.: https://www.ncbi.nlm.nih.gov/pubmed/27881399


Nicotinic receptor activation augments muscarinic receptor-mediated eccrine sweating but not cutaneous vasodilatation in young males. Fujii N, Louie JC, McNeely BD, Zhang SY, Tran MA, Kenny GP. Exp Physiol. 2017 Feb 1;102(2):245-254. doi: 10.1113/EP085916. Epub 2016 Dec 26.:

 https://www.ncbi.nlm.nih.gov/pubmed/27859779


 

Administration of prostacyclin modulates cutaneous blood flow but not sweating in young and older males: roles for nitric oxide and calcium-activated potassium channels. Fujii N, Notley SR, Minson CT, Kenny GP. J Physiol. 2016 Nov 1;594(21):6419-6429. doi: 10.1113/JP273174. Epub 2016 Sep 23.: 

https://www.ncbi.nlm.nih.gov/pubmed/27511105


Nitric oxide synthase and cyclooxygenase modulate β-adrenergic cutaneous vasodilatation and sweating in young men. Fujii N, McNeely BD, Kenny GP. J Physiol. 2017 Feb 15;595(4):1173-1184. doi: 10.1113/JP273502. Epub 2016 Dec 12.: https://www.ncbi.nlm.nih.gov/pubmed/27779753


The effect of endothelin A and B receptor blockade on cutaneous vascular and sweating responses in young men during and following exercise in the heat. Fujii N, Singh MS, Halili L, Louie JC, Kenny GP. J Appl Physiol (1985). 2016 Dec 1;121(6):1263-1271. doi: 10.1152/japplphysiol.00679.2016. Epub 2016 Oct 7.: https://www.ncbi.nlm.nih.gov/pubmed/27763878


Type 1 diabetes modulates cyclooxygenase- and nitric oxide-dependent mechanisms governing sweating but not cutaneous vasodilation during exercise in the heat. Fujii N, Dervis S, Sigal RJ, Kenny GP. Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1;311(6):R1076-R1084. doi: 10.1152/ajpregu.00376.2016. Epub 2016 Oct 12.: https://www.ncbi.nlm.nih.gov/pubmed/27733388


K+ channel mechanisms underlying cholinergic cutaneous vasodilation and sweating in young humans: roles of KCa, KATP, and KV channels? Fujii N, Louie JC, McNeely BD, Zhang SY, Tran MA, Kenny GP. Am J Physiol Regul Integr Comp Physiol. 2016 Sep 1;311(3):R600-6. doi: 10.1152/ajpregu.00249.2016. Epub 2016 Jul 20.: https://www.ncbi.nlm.nih.gov/pubmed/27440718


Cutaneous vascular and sweating responses to intradermal administration of prostaglandin E1 and E2 in young and older adults: a role for nitric oxide? Fujii N, Singh MS, Halili L, Boulay P, Sigal RJ, Kenny GP. Am J Physiol Regul Integr Comp Physiol. 2016 Jun 1;310(11):R1064-72. doi: 10.1152/ajpregu.00538.2015. Epub 2016 Apr 13.: https://www.ncbi.nlm.nih.gov/pubmed/27101302


Cutaneous blood flow during intradermal NO administration in young and older adults: roles for calcium-activated potassium channels and cyclooxygenase? Fujii N, Meade RD, Minson CT, Brunt VE, Boulay P, Sigal RJ, Kenny GP. Am J Physiol Regul Integr Comp Physiol. 2016 Jun 1;310(11):R1081-7. doi: 10.1152/ajpregu.00041.2016. Epub 2016 Apr 6.: https://www.ncbi.nlm.nih.gov/pubmed/27053645


Exploring the mechanisms underpinning sweating: the development of a specialized ventilated capsule for use with intradermal microdialysis. Meade RD, Louie JC, Poirier MP, McGinn R, Fujii N, Kenny GP. Physiol Rep. 2016 Mar;4(6). pii: e12738. doi: 10.14814/phy2.12738. Epub 2016 Mar 31.: https://www.ncbi.nlm.nih.gov/pubmed/27033452


The interactive contributions of Na(+) /K(+) -ATPase and nitric oxide synthase to sweating and cutaneous vasodilatation during exercise in the heat. Louie JC, Fujii N, Meade RD, Kenny GP. J Physiol. 2016 Jun 15;594(12):3453-62. doi: 10.1113/JP271990. Epub 2016 Mar 29.: 

https://www.ncbi.nlm.nih.gov/pubmed/26852741


Endothelin-1 modulates methacholine-induced cutaneous vasodilatation but not sweating in young human skin. Halili L, Singh MS, Fujii N, Alexander LM, Kenny GP. J Physiol. 2016 Jun 15;594(12):3439-52. doi: 10.1113/JP271735. Epub 2016 Mar 11.: https://www.ncbi.nlm.nih.gov/pubmed/26846374


iNOS-dependent sweating and eNOS-dependent cutaneous vasodilation are evident in younger adults, but are diminished in older adults exercising in the heat. Fujii N, Meade RD, Alexander LM, Akbari P, Foudil-Bey I, Louie JC, Boulay P, Kenny GP. J Appl Physiol (1985). 2016 Feb 1;120(3):318-27. doi: 10.1152/japplphysiol.00714.2015. Epub 2015 Nov 19.: https://www.ncbi.nlm.nih.gov/pubmed/26586908


Intradermal administration of ATP augments methacholine-induced cutaneous vasodilation but not sweating in young males and females. Fujii N, Halili L, Singh MS, Meade RD, Kenny GP. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15;309(8):R912-9. doi: 10.1152/ajpregu.00261.2015. Epub 2015 Aug 19.: https://www.ncbi.nlm.nih.gov/pubmed/26290105


Local infusion of ascorbate augments NO-dependent cutaneous vasodilatation during intense exercise in the heat. Meade RD, Fujii N, Alexander LM, Paull G, Louie JC, Flouris AD, Kenny GP. J Physiol. 2015 Sep 1;593(17):4055-65. doi: 10.1113/JP270787. Epub 2015 Jul 28.:

 https://www.ncbi.nlm.nih.gov/pubmed/26110415


Do nitric oxide synthase and cyclooxygenase contribute to the heat loss responses in older males exercising in the heat? Fujii N, Paull G, Meade RD, McGinn R, Stapleton JM, Akbari P, Kenny GP. J Physiol. 2015 Jul 15;593(14):3169-80. doi: 10.1113/JP270330. Epub 2015 May 29.:

 https://www.ncbi.nlm.nih.gov/pubmed/25820454


Angiotensin II in human skin: an age-dependent role for core temperature regulation? McGinn R, Meade RD, Kenny GP. Am J Physiol Heart Circ Physiol. 2015 May 15;308(10):H1192-3. doi: 10.1152/ajpheart.00227.2015. Epub 2015 Mar 27. No abstract available. : 

https://www.ncbi.nlm.nih.gov/pubmed/25820393


Cutaneous vascular and sweating responses to intradermal administration of ATP: a role for nitric oxide synthase and cyclooxygenase? Fujii N, McGinn R, Halili L, Singh MS, Kondo N, Kenny GP. J Physiol. 2015 Jun 1;593(11):2515-25. doi: 10.1113/JP270147. Epub 2015 Apr 17.:

 https://www.ncbi.nlm.nih.gov/pubmed/25809194


Can intradermal administration of angiotensin II influence human heat loss responses during whole body heat stress? Fujii N, Meade RD, Paull G, McGinn R, Foudil-bey I, Akbari P, Kenny GP. J Appl Physiol (1985). 2015 May 1;118(9):1145-53. doi: 10.1152/japplphysiol.00025.2015. Epub 2015 Mar 12.: https://www.ncbi.nlm.nih.gov/pubmed/25767030


Age-related differences in postsynaptic increases in sweating and skin blood flow postexercise. Stapleton JM, Fujii N, McGinn R, McDonald K, Kenny GP. Physiol Rep. 2014 Jul 16;2(7). pii: e12078. doi: 10.14814/phy2.12078.: https://www.ncbi.nlm.nih.gov/pubmed/25347861


Evidence for cyclooxygenase-dependent sweating in young males during intermittent exercise in the heat. Fujii N, McGinn R, Stapleton JM, Paull G, Meade RD, Kenny GP. J Physiol. 2014 Dec 1;592(23):5327-39. doi: 10.1113/jphysiol.2014.280651. Epub 2014 Oct 17. No abstract available. :

 https://www.ncbi.nlm.nih.gov/pubmed/25326453


Cyclooxygenase inhibition does not alter methacholine-induced sweating. Fujii N, McGinn R, Paull G, Stapleton JM, Meade RD, Kenny GP. J Appl Physiol (1985). 2014 Nov 1;117(9):1055-62. doi: 10.1152/japplphysiol.00644.2014. Epub 2014 Sep 11.: https://www.ncbi.nlm.nih.gov/pubmed/25213633


Diminished nitric oxide-dependent sweating in older males during intermittent exercise in the heat. Stapleton JM, Fujii N, Carter M, Kenny GP. Exp Physiol. 2014 Jun;99(6):921-32. doi: 10.1113/expphysiol.2013.077644. Epub 2014 Apr 4.: https://www.ncbi.nlm.nih.gov/pubmed/24706193


Adenosine receptor inhibition attenuates the suppression of postexercise cutaneous blood flow. McGinn R, Fujii N, Swift B, Lamarche DT, Kenny GP. J Physiol. 2014 Jun 15;592(12):2667-78. doi: 10.1113/jphysiol.2014.274068. Epub 2014 Mar 31.: https://www.ncbi.nlm.nih.gov/pubmed/24687586


Sex differences in postsynaptic sweating and cutaneous vasodilation. Gagnon D, Crandall CG, Kenny GP. J Appl Physiol (1985). 2013 Feb;114(3):394-401. doi: 10.1152/japplphysiol.00877.2012. Epub 2012 Nov 15.: https://www.ncbi.nlm.nih.gov/pubmed/23154992